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Detecting Identity by Descent and Estimating Genotype Error Rates in Sequence Data

Existing methods for identity by descent (IBD) segment detection were designed for SNP array data, not sequence data. Sequence data have a much higher density of genetic variants and a different allele frequency distribution, and can have higher genotype error rates. Consequently, best practices for...

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Bibliografske podrobnosti
Main Authors: Browning, Brian L., Browning, Sharon R.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824133/
https://ncbi.nlm.nih.gov/pubmed/24207118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.09.014
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