Structural Analysis of the G-Box Domain of the Microcephaly Protein CPAP Suggests a Role in Centriole Architecture

Centrioles are evolutionarily conserved eukaryotic organelles composed of a protein scaffold surrounded by sets of microtubules organized with a 9-fold radial symmetry. CPAP, a centriolar protein essential for microtubule recruitment, features a C-terminal domain of unknown structure, the G-box. A m...

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Detalhes bibliográficos
Main Authors: Hatzopoulos, Georgios N., Erat, Michèle C., Cutts, Erin, Rogala, Kacper B., Slater, Leanne M., Stansfeld, Philip J., Vakonakis, Ioannis
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
Assuntos:
Short Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824074/
https://ncbi.nlm.nih.gov/pubmed/24076405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.08.019
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