Cyclosporine-inhibitable Blood-Brain Barrier Drug Transport Influences Clinical Morphine Pharmacodynamics

BACKGROUND: The blood-brain barrier is richly populated by active influx and efflux transporters influencing brain drug concentrations. Morphine, a drug with delayed clinical onset, is a substrate for the efflux transporter P-glycoprotein in vitro and in animals. This investigation tested whether mo...

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Main Authors: Meissner, Konrad, Avram, Michael J., Yermolenka, Viktar, Francis, Amber M., Blood, Jane, Kharasch, Evan D.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823830/
https://ncbi.nlm.nih.gov/pubmed/23851346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3182a05bd3
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