THE INSULIN RECEPTOR TRANSLOCATES TO THE NUCLEUS TO REGULATE CELL PROLIFERATION IN LIVER

Insulin’s metabolic effects in the liver are widely appreciated, but insulin’s ability to act as a hepatic mitogen is less well understood. Because the Insulin Receptor (IR) can traffic to the nucleus, and calcium (Ca(2+)) signals within the nucleus regulate cell proliferation, we investigated wheth...

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Hlavní autoři: Amaya, Maria J., Oliveira, André G., Guimarães, Erika S., Casteluber, Marisa C. F., Carvalho, Sandhra M., Andrade, Lidia M., Pinto, Mauro C. X., Mennone, Albert, Oliveira, Cleida A., Resende, Rodrigo R., Menezes, Gustavo B., Nathanson, Michael H., Leite, M. Fatima
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823683/
https://ncbi.nlm.nih.gov/pubmed/23839970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26609
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