MiR-424/503-Mediated Rictor Upregulation Promotes Tumor Progression

mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific component, contributes to tumor progression. Ricto...

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Main Authors: Oneyama, Chitose, Kito, Yoriko, Asai, Rei, Ikeda, Jun-ichiro, Yoshida, Takuya, Okuzaki, Daisuke, Kokuda, Rie, Kakumoto, Kyoko, Takayama, Ken-ichi, Inoue, Satoshi, Morii, Eiichi, Okada, Masato
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823661/
https://ncbi.nlm.nih.gov/pubmed/24244675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080300
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