Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex

Rho-associated kinase (ROCK) plays a critical role in pressure overload-induced left ventricular remodelling. However, the underlying mechanism remains unclear. Here, we reported that TGF-β1-induced ROCK elevation suppressed BMP-2 level and strengthened fibrotic response. Exogenous BMP-2 supply effe...

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Hlavní autoři: Wang, Shijun, Sun, Aijun, Li, Lei, Zhao, Gang, Jia, Jianguo, Wang, Keqiang, Ge, Junbo, Zou, Yunzeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2012
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823423/
https://ncbi.nlm.nih.gov/pubmed/22283839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2012.01538.x
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