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Reduced ligand affinity leads to an impaired function of the adenosine A(2A) receptor of human granulocytes in sepsis

The enhanced release of reactive oxygen species by excessively activated polymorphonuclear leucocytes (PMN) is a key step in the pathogenesis of sepsis. Potent action of adenosine in inhibiting cytotoxic PMN functions has been documented. Recent data, however provide evidence that in sepsis a dimini...

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Bibliografische gegevens
Hoofdauteurs: Kreth, Simone, Kaufmann, Ines, Ledderose, Carola, Luchting, Benjamin, Thiel, Manfred
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823413/
https://ncbi.nlm.nih.gov/pubmed/19538256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00530.x
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