A possible role of thymidine phosphorylase expression and5-fluorouracil increased sensitivity in oropharyngeal cancer patients

Thymidine Pi deoxyribosyltransferase (TP) is an enzyme involved in DNA synthesis up-regulated in tumours and it is also a pro-angiogenic factor. TP cannot activate capecitabine, because capecitabine first needs conversion by carboxylesterase and cytidine deaminase into 5-deoxy-fluorouridine. This co...

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Главные авторы: Ranieri, G, Grammatica, L, Patruno, R, Zito, AF, Valerio, P, Iacobellis, S, Gadaleta, C, Gasparini, G, Ribatti, D
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2007
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822834/
https://ncbi.nlm.nih.gov/pubmed/17378915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2007.00007.x
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