TFPI-2 silencing increases tumour progression and promotes metalloproteinase 1 and 3 induction through tumour-stromal cell interactions

Tissue factor pathway inhibitor-2 (TFPI-2) is a potent inhibitor of plasmin which activates matrix metalloproteinases (MMPs) involved in degradation of the extracellular matrix. Its secretion in the tumour microenvironment makes TFPI-2 a potential inhibitor of tumour invasion and metastasis. As demo...

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Autors principals: Gaud, Guillaume, Iochmann, Sophie, Guillon-Munos, Audrey, Brillet, Benjamin, Petiot, Stéphanie, Seigneuret, Florian, Touzé, Antoine, Heuzé-Vourc’h, Nathalie, Courty, Yves, Lerondel, Stéphanie, Gruel, Yves, Reverdiau, Pascale
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822788/
https://ncbi.nlm.nih.gov/pubmed/20015200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00989.x
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