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Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase

Recent reports have suggested that statins induce cell death in certain epithelial cancers and that patients taking statins to reduce cholesterol levels possess lower cancer incidence. However, little is known about the mechanisms of action of different statins or the effects of these statins in gyn...

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Autors principals: Kato, S, Smalley, S, Sadarangani, A, Chen-Lin, K, Oliva, B, Brañes, J, Carvajal, J, Gejman, R, Owen, G I, Cuello, M
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822754/
https://ncbi.nlm.nih.gov/pubmed/19432822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00771.x
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