Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against tumours not located in bone. Mice transgenic for the activated ErbB-2 oncogene were treated with a cumulative number of doses equivalent to that recommended in human beings. A significant increase in tumour-fre...

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Detalhes bibliográficos
Main Authors: Coscia, Marta, Quaglino, Elena, Iezzi, Manuela, Curcio, Claudia, Pantaleoni, Francesca, Riganti, Chiara, Holen, Ingunn, Mönkkönen, Hannu, Boccadoro, Mario, Forni, Guido, Musiani, Piero, Bosia, Amalia, Cavallo, Federica, Massaia, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822730/
https://ncbi.nlm.nih.gov/pubmed/19818098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00926.x
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