Potential use of additivity of mutational effects in simplifying protein engineering.
The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are addit...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.10753 |
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