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Competition of zinc ion for the [2Fe–2S] cluster binding site in the diabetes drug target protein mitoNEET
Human mitochondrial protein mitoNEET is a novel target of type II diabetes drug pioglitazone, and contains a redox active [2Fe–2S] cluster that is hosted by a unique ligand arrangement of three cysteine and one histidine residues. Here we report that zinc ion can compete for the [2Fe–2S] cluster bin...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3822609/ https://ncbi.nlm.nih.gov/pubmed/22945239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-012-9580-4 |
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