PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1

Malignant Pleural Mesothelioma (MMe) is a rare but increasingly prevalent, highly aggressive cancer with poor prognosis. The aetiology of MMe is essentially a function of previous exposure to asbestos fibres, which are considered to be an early-stage carcinogen. Asbestos is toxic to human mesothelia...

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Autors principals: Pinton, Giulia, Manente, Arcangela Gabriella, Murer, Bruno, Marino, Elvira, Mutti, Luciano, Moro, Laura
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822586/
https://ncbi.nlm.nih.gov/pubmed/23301673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12000
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