Analysis of Fcγ Receptor IIIa and IIa Polymorphisms: Lack of Correlation with Outcome in Trastuzumab-Treated Breast Cancer Patients

PURPOSE: The mechanisms by which trastuzumab imparts clinical benefit remain incompletely understood. Antibody-dependent cellular cytotoxicity via interactions with Fcγ receptors (FcγR) on leukocytes may contribute to its anti-tumor effects. Single nucleotide polymorphisms (SNPs) in FCGR3A and FCGR2...

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Main Authors: Hurvitz, Sara A., Betting, David J., Stern, Howard M., Quinaux, Emmanuel, Stinson, Jeremy, Seshagiri, Somasekar, Zhao, Ying, Buyse, Marc, Mackey, John, Driga, Adrian, Damaraju, Sambasivarao, Sliwkowski, Mark X., Robert, Nicholas J., Valero, Vicente, Crown, John, Falkson, Carla, Brufsky, Adam, Pienkowski, Tadeusz, Eiermann, Wolfgang, Martin, Miguel, Bee, Valerie, Marathe, Omkar, Slamon, Dennis J., Timmerman, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821872/
https://ncbi.nlm.nih.gov/pubmed/22504044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2294
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