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DELETION OF RETINOIC ACID RECEPTOR β (RARβ) IMPAIRS PANCREATIC ENDOCRINE DIFFERENTIATION
All-trans retinoic acid (RA) signals via binding to retinoic acid receptors (RARs α, β, and γ). RA directly influences expression of Pdx1, a transcription factor essential for pancreatic development and β-cell maturation. In this study we follow the differentiation of cultured wild-type (WT) vs. RAR...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821387/ https://ncbi.nlm.nih.gov/pubmed/23756134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.05.032 |
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