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Identification of Conformationally Sensitive Residues Essential for Inhibition of Vesicular Monoamine Transport by the Noncompetitive Inhibitor Tetrabenazine

Vesicular monoamine transporter 2 (VMAT2) transports monoamines into storage vesicles in a process that involves exchange of the charged monoamine with two protons. VMAT2 is a member of the DHA12 family of multidrug transporters that belongs to the major facilitator superfamily of secondary transpor...

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Autores principales: Ugolev, Yelena, Segal, Tali, Yaffe, Dana, Gros, Yael, Schuldiner, Shimon
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820856/
https://ncbi.nlm.nih.gov/pubmed/24062308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.502971
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