CDK5RAP2 is required for spindle checkpoint function

The combination of paclitaxel and doxorubicin is among the most successful chemotherapy regimens in cancer treatment. CDK5RAP2, when mutated, causes primary microcephaly. We show here that inhibition of CDK5RAP2 expression causes chromosome mis-segregation, fails to maintain the spindle checkpoint,...

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Bibliografiske detaljer
Main Authors: Zhang, Xiaoying, Liu, Dongyun, Lv, Shuang, Wang, Haibo, Zhong, Xueyan, Liu, Bo, Wang, Bo, Liao, Ji, Li, Jing, Pfeifer, Gerd P., Xu, Xingzhi
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2009
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820842/
https://ncbi.nlm.nih.gov/pubmed/19282672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.8.8.8205
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