CDK5RAP2 is required for spindle checkpoint function

The combination of paclitaxel and doxorubicin is among the most successful chemotherapy regimens in cancer treatment. CDK5RAP2, when mutated, causes primary microcephaly. We show here that inhibition of CDK5RAP2 expression causes chromosome mis-segregation, fails to maintain the spindle checkpoint,...

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Autors principals: Zhang, Xiaoying, Liu, Dongyun, Lv, Shuang, Wang, Haibo, Zhong, Xueyan, Liu, Bo, Wang, Bo, Liao, Ji, Li, Jing, Pfeifer, Gerd P., Xu, Xingzhi
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820842/
https://ncbi.nlm.nih.gov/pubmed/19282672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.8.8.8205
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