Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease

Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We investigated the effect of Rac-1 and Rho kina...

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Detalhes bibliográficos
Main Authors: Babelova, Andrea, Jansen, Felix, Sander, Kerstin, Löhn, Matthias, Schäfer, Liliana, Fork, Christian, Ruetten, Hartmut, Plettenburg, Oliver, Stark, Holger, Daniel, Christoph, Amann, Kerstin, Pavenstädt, Hermann, Jung, Oliver, Brandes, Ralf P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820652/
https://ncbi.nlm.nih.gov/pubmed/24244677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080328
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