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Stability of Transmembrane Amyloid β-Peptide and Membrane Integrity Tested by Molecular Modeling of Site-Specific Aβ (42) Mutations
Interactions of the amyloid β-protein (Aβ) with neuronal cell membranes, leading to the disruption of membrane integrity, are considered to play a key role in the development of Alzheimer’s disease. Natural mutations in Aβ (42), such as the Arctic mutation (E22G) have been shown to increase Aβ (42)...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820573/ https://ncbi.nlm.nih.gov/pubmed/24244308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078399 |
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