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Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity
Small drug molecules usually bind to multiple protein targets or even unintended off-targets. Such drug promiscuity has often led to unwanted or unexplained drug reactions, resulting in side effects or drug repositioning opportunities. So it is always an important issue in pharmacology to identify p...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820513/ https://ncbi.nlm.nih.gov/pubmed/24244130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003315 |
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