Mutations in the C-terminal fragment of DnaK affecting peptide binding.

Escherichia coli DnaK acts as a molecular chaperone through its ATP-regulated binding and release of polypeptide substrates. Overexpressing a C-terminal fragment (CTF) of DnaK (Gly-384 to Lys-638) containing the polypeptide substrate binding domain is lethal in wild-type E. coli. This dominant-negat...

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Bibliografiske detaljer
Main Authors: Burkholder, W F, Zhao, X, Zhu, X, Hendrickson, W A, Gragerov, A, Gottesman, M E
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC38205/
https://ncbi.nlm.nih.gov/pubmed/8855230
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