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Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy: The Underlying Mechanisms and Clinical Management
Immunomodulation with the anti-CTLA-4 monoclonal antibody ipilimumab has been shown to extend overall survival (OS) in previously treated and treatment-naive patients with unresectable stage III or IV melanoma. Blockade of CTLA-4 signaling with ipilimumab prolongs T-cell activation and restores T-ce...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820355/ https://ncbi.nlm.nih.gov/pubmed/24278787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/857519 |
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