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A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival. Delineating the relative contribution of these two disease mechanisms is a major challeng...

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書誌詳細
主要な著者: Gualeni, Benedetta, Rajpar, M. Helen, Kellogg, Aaron, Bell, Peter A., Arvan, Peter, Boot-Handford, Raymond P., Briggs, Michael D.
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists Limited 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820264/
https://ncbi.nlm.nih.gov/pubmed/24046357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.013342
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