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Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation

Disruption to endochondral ossification leads to delayed and irregular bone formation and can result in a heterogeneous group of genetic disorders known as the chondrodysplasias. One such disorder, multiple epiphyseal dysplasia (MED), is characterized by mild dwarfism and early-onset osteoarthritis...

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Detalhes bibliográficos
Main Authors: Leighton, Matthew P., Nundlall, Seema, Starborg, Tobias, Meadows, Roger S., Suleman, Farhana, Knowles, Lynette, Wagener, Raimund, Thornton, David J., Kadler, Karl E., Boot-Handford, Raymond P., Briggs, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674230/
https://ncbi.nlm.nih.gov/pubmed/17517694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddm121
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