A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival. Delineating the relative contribution of these two disease mechanisms is a major challeng...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gualeni, Benedetta, Rajpar, M. Helen, Kellogg, Aaron, Bell, Peter A., Arvan, Peter, Boot-Handford, Raymond P., Briggs, Michael D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Limited 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820264/
https://ncbi.nlm.nih.gov/pubmed/24046357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.013342
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