A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival. Delineating the relative contribution of these two disease mechanisms is a major challeng...

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Bibliographische Detailangaben
Hauptverfasser: Gualeni, Benedetta, Rajpar, M. Helen, Kellogg, Aaron, Bell, Peter A., Arvan, Peter, Boot-Handford, Raymond P., Briggs, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Limited 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820264/
https://ncbi.nlm.nih.gov/pubmed/24046357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.013342
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