Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD is caused by chronic exposure to cigarette smoke and/or other environmental pollutants that are believed to induce reactive oxygen species (ROS) that gradually disrupt signalling pathways respo...

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Main Authors: Heidler, Juliana, Fysikopoulos, Athanasios, Wempe, Frank, Seimetz, Michael, Bangsow, Thorsten, Tomasovic, Ana, Veit, Florian, Scheibe, Susan, Pichl, Alexandra, Weisel, Friederike, Lloyd, K. C. Kent, Jaksch, Peter, Klepetko, Walter, Weissmann, Norbert, von Melchner, Harald
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Limited 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820261/
https://ncbi.nlm.nih.gov/pubmed/24046361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.013482
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