SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

Sorting nexins (SNXs) are key regulators of the endosomal network. In designing an RNAi-mediated loss-of-function screen, we establish that of 30 human SNXs only SNX3, SNX5, SNX9, SNX15 and SNX21 appear to regulate EGF receptor degradative sorting. Suppression of SNX15 results in a delay in receptor...

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Detalhes bibliográficos
Main Authors: Danson, Chris, Brown, Edward, Hemmings, Oliver J., McGough, Ian J., Yarwood, Sam, Heesom, Kate J., Carlton, Jeremy G., Martin-Serrano, Juan, May, Margaret T., Verkade, Paul, Cullen, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820240/
https://ncbi.nlm.nih.gov/pubmed/23986476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.125732
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