Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice

Neurofibromatosis type 1 (NF1) is a common genetic disorder affecting 1 in 3500 individuals. Patients with NF1 are predisposed to debilitating skeletal manifestations, including osteopenia/osteoporosis and long bone pseudarthrosis (nonunion fracture). Hyperactivation of the Ras/mitogen-activated pro...

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Hoofdauteurs: Sharma, Richa, Wu, Xiaohua, Rhodes, Steven D., Chen, Shi, He, Yongzheng, Yuan, Jin, Li, Jiliang, Yang, Xianlin, Li, Xiaohong, Jiang, Li, Kim, Edward T., Stevenson, David A., Viskochil, David, Xu, Mingjiang, Yang, Feng-Chun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820137/
https://ncbi.nlm.nih.gov/pubmed/23863460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt333
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