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Lipoic Acid Restores Age-Associated Impairment of Brain Energy Metabolism through the Modulation of Akt/JNK Signaling and PGC1α Transcriptional Pathway

This study examines the progress of a hypometabolic state inherent in brain aging with an animal model consisting of Fischer 344 rats of young, middle, and old ages. Dynamic microPET scanning demonstrated a significant decline in brain glucose uptake at old ages, which was associated with a decrease...

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Detalhes bibliográficos
Main Authors: Jiang, Tianyi, Yin, Fei, Yao, Jia, Brinton, Roberta Díaz, Cadenas, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819405/
https://ncbi.nlm.nih.gov/pubmed/23815272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12127
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