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SILENCING OF NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE IMPAIRS CELLULAR REDOX HOMEOSTASIS AND ENERGY METABOLISM IN PC12 CELLS
Mitochondrial NADPH generation is largely dependent on the inner-membrane Nicotinamide Nucleotide Transhydrogenase (NNT), which catalyzes the reduction of NADP(+) to NADPH utilizing the proton gradient as the driving force and NADH as the electron donor. Small interfering RNA (siRNA) silencing of NN...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3269566/ https://ncbi.nlm.nih.gov/pubmed/22198343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2011.12.004 |
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