Addition of Exogenous NAD(+) Prevents Mefloquine-Induced Neuroaxonal and Hair Cell Degeneration through Reduction of Caspase-3-Mediated Apoptosis in Cochlear Organotypic Cultures

BACKGROUND: Mefloquine is widely used for the treatment of malaria. However, this drug is known to induce neurological side effects including depression, anxiety, balance disorder, and sensorineural hearing loss. Yet, there is currently no treatment for these side effects. PRINCIPAL FINDINGS: In thi...

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Detalhes bibliográficos
Main Authors: Ding, Dalian, Qi, Weidong, Yu, Dongzhen, Jiang, Haiyan, Han, Chul, Kim, Mi-Jung, Katsuno, Kana, Hsieh, Yun Hua, Miyakawa, Takuya, Salvi, Richard, Tanokura, Masaru, Someya, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819247/
https://ncbi.nlm.nih.gov/pubmed/24223197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079817
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