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Genome‐wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

To increase production of the important pharmaceutical compound clavulanic acid, a β‐lactamase inhibitor, both random mutagenesis approaches and rational engineering of Streptomyces clavuligerus strains have been extensively applied. Here, for the first time, we compared genome‐wide gene expression...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Medema, Marnix H., Alam, Mohammad T., Heijne, Wilbert H. M., van den Berg, Marco A., Müller, Ulrike, Trefzer, Axel, Bovenberg, Roel A. L., Breitling, Rainer, Takano, Eriko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818869/
https://ncbi.nlm.nih.gov/pubmed/21342474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1751-7915.2010.00226.x
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