Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection

We investigated the crystal structure of an HLA-A*2402-restricted CTL epitope in the HIV-1 nef gene (Nef134-10) before (pHLA) or after TCR docking. The wild type epitope and two escape mutants were included in the study. Y135F was an early-appearing major mutation, while F139L was a late-appearing m...

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Auteurs principaux: Shimizu, Akihisa, Kawana-Tachikawa, Ai, Yamagata, Atsushi, Han, Chungyong, Zhu, Dayong, Sato, Yusuke, Nakamura, Hitomi, Koibuchi, Tomohiko, Carlson, Jonathan, Martin, Eric, Brumme, Chanson J., Shi, Yi, Gao, George F., Brumme, Zabrina L., Fukai, Shuya, Iwamoto, Aikichi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818656/
https://ncbi.nlm.nih.gov/pubmed/24192765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03097
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