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Light Activation of the Insulin Receptor Regulates Mitochondrial Hexokinase. A Possible Mechanism of Retinal Neuroprotection
The serine/threonine kinase Akt has been shown to mediate the anti-apoptotic activity through hexokinase (HK)-mitochondria interaction. We previously reported that Akt activation in retinal rod photoreceptor cells is mediated through light-dependent insulin receptor (IR)/PI3K pathway. Our data indic...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3818532/ https://ncbi.nlm.nih.gov/pubmed/23993956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2013.08.005 |
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