Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-induced Glioma Cells

eNOS expression is elevated in human glioblastomas and correlated with increased tumor growth and aggressive character. We investigated the potential role of nitric oxide (NO) activity in the perivascular niche (PVN) using a genetic engineered mouse model of PDGF-induced gliomas. eNOS expression is...

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Autori principali: Charles, Nikki, Ozawa, Tatsuya, Squatrito, Massimo, Bleau, Anne-Marie, Brennan, Cameron W., Hambardzumyan, Dolores, Holland, Eric C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818090/
https://ncbi.nlm.nih.gov/pubmed/20144787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.01.001
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