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Enantioselective Construction of α-Quaternary Cyclobutanones by Catalytic Asymmetric Allylic Alkylation

No Strain, No Gain! The first transition metal-catalyzed enantioselective α-alkylation of cyclobutanones is reported. This method employs palladium catalysis and an electron deficient PHOX type ligand to afford all–carbon α-quaternary cyclobutanones in good to excellent yields and enantioselectiviti...

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Bibliografiske detaljer
Main Authors: Reeves, Corey M., Eidamshaus, Christian, Kim, Jimin, Stoltz, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817853/
https://ncbi.nlm.nih.gov/pubmed/23686812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201301815
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