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Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification
A highly efficient synthesis of enantiomerically pure (S) and (R)-isomers of N-(2,3-dihydroxypropyl)arylamides has been developed with good overall yields in a two step process. The key step involves the ring opening of the chiral epoxide with a nitrogen heterocyclic carbene (NHC) and further rearra...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3817507/ https://ncbi.nlm.nih.gov/pubmed/24204425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.250 |
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