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RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core
Although U snRNAs play essential roles in splicing, little is known about the 3D arrangement of U2, U6, and U5 snRNAs and the pre-mRNA in active spliceosomes. To elucidate their relative spatial organization and dynamic rearrangement, we examined the RNA structure of affinity-purified, human spliceo...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
European Molecular Biology Organization
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3817461/ https://ncbi.nlm.nih.gov/pubmed/24002212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.198 |
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