A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells

Pluripotency in embryonic stem cells is maintained through the activity of a small set of transcription factors centred around Oct4 and Nanog, which control the expression of ‘self-renewal’ and ‘differentiation’ genes. Here, we combine single-cell quantitative immunofluorescence microscopy and gene...

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Autores principales: Muñoz Descalzo, Silvia, Rué, Pau, Faunes, Fernando, Hayward, Penelope, Jakt, Lars Martin, Balayo, Tina, Garcia-Ojalvo, Jordi, Martinez Arias, Alfonso
Formato: Artigo
Lenguaje:Inglês
Publicado: European Molecular Biology Organization 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817399/
https://ncbi.nlm.nih.gov/pubmed/24104477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.49
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