Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that undergoes extensive phase I and II metabolism. To better understand the kinetics of this process and to characterize the dynamic changes in metabolism and pharmacokinetics (PK) between children and adults, we developed a physi...

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Detalhes bibliográficos
Main Authors: Jiang, X-L, Zhao, P, Barrett, J S, Lesko, L J, Schmidt, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817375/
https://ncbi.nlm.nih.gov/pubmed/24132164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.55
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