Application of Physiologically Based Pharmacokinetic Modeling to Predict Pharmacokinetics in Healthy Japanese Subjects

Pharmacokinetics (PKs) in Japanese healthy subjects were simulated for nine compounds using physiologically based PK (PBPK) models parameterized with physicochemical properties, preclinical absorption, distribution, metabolism, and excretion (ADME) data, and clinical PK data from non‐Japanese subjec...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Matsumoto, Yuki, Cabalu, Tamara, Sandhu, Punam, Hartmann, Georgy, Iwasa, Takashi, Yoshitsugu, Hiroyuki, Gibson, Christopher, Uemura, Naoto
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587435/
https://ncbi.nlm.nih.gov/pubmed/30252941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1240
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