The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

Regulatory T (Treg) cells suppress inflammatory immune responses and autoimmunity caused by self-reactive T cells. The key Treg cell transcription factor Foxp3 is downregulated during inflammation to allow for the acquisition of effector T cell-like functions. Here, we demonstrate that stress signal...

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Main Authors: Chen, Zuojia, Barbi, Joseph, Bu, Shurui, Yang, Huang-Yu, Li, Zhiyuan, Gao, Yayi, Jinasena, Dilini, Fu, Juan, Lin, Fang, Chen, Chen, Zhang, Jing, Yu, Ning, Li, Xiangpei, Shan, Zhao, Nie, Jia, Gao, Zhimei, Tian, Hong, Li, Yangyang, Yao, Zhengju, Zheng, Ying, Park, Benjamin V., Pan, Ziyi, Dang, Eric, Li, Zhiguang, Wang, Honglin, Luo, Weibo, Li, Liwu, Semenza, Gregg L., Zheng, Song-Guo, Loser, Karin, Tsun, Andy, Greene, Mark I., Pardoll, Drew M., Pan, Fan, Li, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817295/
https://ncbi.nlm.nih.gov/pubmed/23973223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.08.006
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