Prolonged Bioluminescence Monitoring in Mouse Ex Vivo Bone Culture Revealed Persistent Circadian Rhythms in Articular Cartilages and Growth Plates

The bone is a metabolically active organ which undergoes repeated remodeling cycles of bone resorption and formation. In this study, we revealed a robust and extremely long-lasting circadian rhythm in ex vivo culture maintained for over six months from the femoral bone of a PERIOD2(Luciferase) mouse...

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Autores principales: Okubo, Naoki, Minami, Yoichi, Fujiwara, Hiroyoshi, Umemura, Yasuhiro, Tsuchiya, Yoshiki, Shirai, Toshiharu, Oda, Ryo, Inokawa, Hitoshi, Kubo, Toshikazu, Yagita, Kazuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817244/
https://ncbi.nlm.nih.gov/pubmed/24223788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078306
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