Prominent Heart Organ-Level Performance Deficits in a Genetic Model of Targeted Severe and Progressive SERCA2 Deficiency

The cardiac SERCA2 Ca(2+) pump is critical for maintaining normal Ca(2+) handling in the heart. Reduced SERCA2a content and blunted Ca(2+) reuptake are frequently observed in failing hearts and evidence implicates poor cardiac Ca(2+) handling in the progression of heart failure. To gain insight into...

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Detaylı Bibliyografya
Asıl Yazarlar: Heinis, Frazer I., Andersson, Kristin B., Christensen, Geir, Metzger, Joseph M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817129/
https://ncbi.nlm.nih.gov/pubmed/24223976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079609
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