Tumor Stiffness Is Unrelated to Myosin Light Chain Phosphorylation in Cancer Cells

Many tumors are stiffer than their surrounding tissue. This increase in stiffness has been attributed, in part, to a Rho-dependent elevation of myosin II light chain phosphorylation. To characterize this mechanism further, we studied myosin light chain kinase (MLCK), the main enzyme that phosphoryla...

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Main Authors: Yu, Hui-Jun, Serebryannyy, Leonid A., Fry, Madeline, Greene, Madelyne, Chernaya, Olga, Hu, Wen-Yang, Chew, Teng-Leong, Mahmud, Nadim, Kadkol, Shrihari S., Glover, Sarah, Prins, Gail, Strakova, Zuzana, de Lanerolle, Primal
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817105/
https://ncbi.nlm.nih.gov/pubmed/24224004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079776
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