A Composite Functional Genetic and Co-Medication CYP2D6 Activity Score In Predicting Tamoxifen Drug Exposure Among Breast Cancer Patients

BACKGROUND: Accurate assessment of CYP2D6 phenotypes from genotype is inadequate in patients taking CYP2D6 substrate together with CYP2D6 inhibitors. We propose a novel CYP2D6 scoring systems that incorporates the impact of concomitant medications with the genotype in calculating the CYP2D6 activity...

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Detaylı Bibliyografya
Asıl Yazarlar: Borges, Silvana, Desta, Zeruesenay, Jin, Yan, Faouzi, Azzouz, Robarge, Jason D., Philip, Santosh, Nguyen, Anne, Stearns, Vered, Hayes, Daniel, Rae, James M., Skaar, Todd C., Flockhart, David A., Li, Lang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816977/
https://ncbi.nlm.nih.gov/pubmed/20081063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270009359182
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