Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

PURPOSE: Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant of treatment response. Dose-dense (DD) temozolomide results in prolonged...

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Main Authors: Gilbert, Mark R., Wang, Meihua, Aldape, Kenneth D., Stupp, Roger, Hegi, Monika E., Jaeckle, Kurt A., Armstrong, Terri S., Wefel, Jeffrey S., Won, Minhee, Blumenthal, Deborah T., Mahajan, Anita, Schultz, Christopher J., Erridge, Sara, Baumert, Brigitta, Hopkins, Kristen I., Tzuk-Shina, Tzahala, Brown, Paul D., Chakravarti, Arnab, Curran, Walter J., Mehta, Minesh P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2013
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816958/
https://ncbi.nlm.nih.gov/pubmed/24101040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.49.6968
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