Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

PURPOSE: Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant of treatment response. Dose-dense (DD) temozolomide results in prolonged...

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Main Authors: Gilbert, Mark R., Wang, Meihua, Aldape, Kenneth D., Stupp, Roger, Hegi, Monika E., Jaeckle, Kurt A., Armstrong, Terri S., Wefel, Jeffrey S., Won, Minhee, Blumenthal, Deborah T., Mahajan, Anita, Schultz, Christopher J., Erridge, Sara, Baumert, Brigitta, Hopkins, Kristen I., Tzuk-Shina, Tzahala, Brown, Paul D., Chakravarti, Arnab, Curran, Walter J., Mehta, Minesh P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Clinical Oncology 2013
Ábhair:
Original Reports
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816958/
https://ncbi.nlm.nih.gov/pubmed/24101040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.49.6968
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