Melanocytes and Pigmentation Are Affected in Dopachrome Tautomerase Knockout Mice

The tyrosinase family comprises three members, tyrosinase (Tyr), tyrosinase-related protein 1 (Tyrp1), and dopachrome tautomerase (Dct). Null mutations and deletions at the Tyr and Tyrp1 loci are known and phenotypically affect coat color due to the absence of enzyme or intracellular mislocalization...

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Main Authors: Guyonneau, Laurence, Murisier, Fabien, Rossier, Anita, Moulin, Alexandre, Beermann, Friedrich
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC381679/
https://ncbi.nlm.nih.gov/pubmed/15060160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.8.3396-3403.2004
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